Ghazal Jamirad
Contact details
Thesis title
Computational Modelling of interactions of Antimicrobial Peptides with Bacterial Cell Membranes
Research overview
Multidrug resistance to conventional antibiotics represents a critical global health challenge, driving the urgent need for effective and biocompatible antimicrobial alternatives. Structurally Nanoengineered Antimicrobial Peptide Polymers (SNAPPs) have emerged as a promising solution. SNAPPs composed of Amino Acids blocks display sub-micromolar activity against both Gram-negative and Gram-positive bacteria, with cryo-TEM revealing multimodal antibacterial action. However, the underlying molecular mechanisms remain unclear. Our work employs molecular dynamics simulations to investigate SNAPP–bacterial envelope interactions, enabling rational design and optimization of next-generation SNAPPs with enhanced and accelerated antibacterial activity.
Research group
Integrated Computational Materials Group (ICME)
Supervisors
Qualifications
B.Sc. Materials Science and Engineering, K. N. Toosi University of Technology, Iran (2018)
M.Eng. Materials Engineering, K. N. Toosi University of Technology, Iran (2022)